1. Active Pharmaceutical Ingredient (API):
Role: The API is
the primary medicinal compound in the tablet, responsible for the therapeutic
effect. It's typically present in a specific dose to treat a particular medical
condition.
2. Excipients:
Role: Excipients
are inactive ingredients that help to process and formulate the tablet. They
serve various functions, including:
Binder: Holds the
tablet particles together, ensuring the tablet remains intact after
compression.
Filler (Diluent):
Increases the tablet's bulk, making it the right size and aiding in uniform
drug distribution.
Disintegrant:
Promotes tablet disintegration in the digestive system, allowing for drug
release and absorption.
Lubricant:
Reduces friction between tablet particles and the tablet press, facilitating
the manufacturing process.
Glidant (Flow
enhancer): Improves powder flowability during tablet production.
Coloring agents
and flavoring agents: Used for aesthetic and taste considerations, especially
for chewable or orally disintegrating tablets.
3. Binders:
Role: Binders are
essential to hold the tablet ingredients together and ensure the tablet
maintains its structural integrity.
4. Fillers (Diluents):
Role: Fillers are
added to increase the bulk of the tablet, ensuring that it's the right size for
handling and swallowing. They may also aid in uniform drug distribution.
5. Disintegrants:
Role: Disintegrants
promote the rapid breakup of the tablet when it comes into contact with liquids
in the gastrointestinal tract. This facilitates drug release and absorption.
6. Lubricants:
Role: Lubricants
reduce friction between the tablet particles and the tablet press during
manufacturing. This ensures that the tablet can be efficiently compressed
without sticking to the equipment.
7. Glidants (Flow Enhancers):
Role: Glidants
improve the flowability of the powdered tablet ingredients, making them easier
to handle during the manufacturing process.
8. Coating Agents (for coated tablets):
Role: Coating
agents are used to apply a protective or functional coating to the tablet. This
coating can serve various purposes, including:
Enteric coating:
Protects the drug from stomach acid, releasing it in the intestines.
Film coating:
Provides an attractive appearance, taste masking, and controlled drug release.
9. Coloring Agents and Flavoring Agents (for chewable or
orally disintegrating tablets):
Role: These agents
enhance the tablet's appearance and taste, making it more palatable for
patients.
10. Disintegration and dissolution enhancers:
Role: These
ingredients help improve the tablet's disintegration and dissolution
properties, ensuring the drug is released and absorbed effectively in the body.
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